Rebecca Naa Okaikor Akufo-Addo (née Griffiths-Randolph; born 1951)  is a Ghanaian public figure and the current First Lady of Ghana as the wife of President Nana Akufo-Addo, 5th President of the 4th Republic of Ghana.
Akufo-Addo is the daughter of the judge, Jacob Hackenburg Griffiths-Randolph who served as the Speaker of the Parliament of Ghana in Third Republic and Frances Phillipina Griffiths-Randolph (née Mann). After graduating from Achimota Primary School and Wesley Grammar School, both in Accra, she furthered her education at the Government Secretarial School and became a secretary.
She subsequently worked as a secretary at the Merchant Bank in Ghana and later relocated to United Kingdom and worked as a legal secretary for Clifford Chance/Ashurst Morris Crisp, multinational law firms in the United Kingdom.
As First lady, Akufo-Addo has been praised for advocating the fight of the disease Malaria in Ghana and has been recognized as a nutrition champion for fighting against malnutrition in children and adolescents, and outstanding contribution to women’s health and efforts against infant mortality in Ghana and across Africa. In 2017, she established the Rebecca Akufo-Addo foundation, a non-governmental organization with a mission to enhance efforts of the government amongst Ghanaian women and children.
Rebecca Akufo-Addo was born on the 12th of March 1951 as the daughter of the judge, Jacob Hackenburg Griffiths-Randolph who served as the Speaker of the Parliament of Ghana in Third Republic and Frances Phillipina Griffiths-Randolph (née Mann). She attended Achimota Primary School and Wesley Grammar School, both in Accra.
Rebecca Akufo-Addo furthered her education at the Government Secretarial School where she qualified as a secretary. She worked at the Merchant Bank in Ghana and later relocated to United Kingdom. She then worked as a legal secretary for Clifford Chance/Ashurst Morris Crisp, multinational law firms in the United Kingdom.
In November 2016, she made a donation of bags of rice, cartons of milo, gallons of cooking oil, bag of sugar, boxes of noodles, toiletries, detergents, boxes of tooth paste and cartons of drinks to the Accra Psychiatric Hospital. This was to help with personal hygiene of the inmates. In 2017 and 2020, she donated food items to Ga-Mashie and Tema Traditional Councils respectively to support in the celebration of their annual Homowo festival.
In August 2020, Rebecca Akufo-Addo made a donation of $20,000 to help Emmanuel Apraku, a pencil artist treat a liver disease he was battling. In the same month of August 2020 she donated temperature guns to the Ghana Library Board, to be shared to the libraries across the country. This was to help curb the spread of the COVID-19 pandemic by checking the temperatures of people who came to use the libraries. In September 2020, she donated some items to the University of Ghana Teaching Hospital. The items included five beds sets, powdered soap, baby diapers, blankets, bedsheets, patient monitors, thermometer guns, 20 gallons of hand sanitizer, nose masks and delivery bowls.