The 2021–22 Serbian SuperLiga will be the 16th season of the Serbian SuperLiga since its establishment in 2006. Red Star are the defending champions, having won their 7th SuperLiga and 32nd domestic title in the previous season. Start and end dates, fixtures and competition format were released on 22 June 2021.
Number of teams in the league for this season was reduced from 20 to 16 from last season which had increased number of teams due to COVID-19 pandemic. Before the start of the season, on 16 June 2021, it was announced that number of teams in the league will again be reduced at the end of season – this time to 14. Because of that 4 teams will be relegated while only 2 will be promoted from Serbian First League. Rule about bonus players was also changed for this season – each team now must have at least one player born in 2000 or younger in the squad for the duration of entire match.
Decision about decreasing number of teams for a next season was revised on 6 July 2021 when Football Association of Serbia decided that number of teams in top flight will remain 16. Format was officially reverted to the one used in 19–20 season – each time will play each other twice in round-robin format after which top half will play in Championship round and bottom half in Relegation round Play-offs. Last two teams from Relegation round will be relegated while teams finishing 13th and 14th will play Relegations play-off against teams who finished 3rd and 4th in Serbian First League. Rule about foreign players registration was also changed. Instead of maximum of 4 foreign players in match protocol teams can now have unlimited number of foreign players with maximum of 4 at the pitch at any time. For the first time in Serbian SuperLiga history Video assistant referee will be used on all matches.
This season marked the start of a new three-year TV deal. Deal was signed with Telekom Srbija and their subsidiary Arena Channels Group. They will pay 3 million-a-year for the next three seasons, a record breaking deal for Serbian SuperLiga.